Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology
| Autor: | Silvia López-Argüello, Maria Montaner, Alaa RM. Sayed, Antonio Oliver, Jürgen B. Bulitta, Bartolome Moya |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Antimicrobial Agents and Chemotherapy. |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01603-22 |
| Popis: | The β-lactam antibiotics have been successfully used for decades to combat susceptible Pseudomonas aeruginosa , which has a notoriously difficult to penetrate outer membrane (OM). However, there is a dearth of data on target site penetration and covalent binding of penicillin-binding proteins (PBP) for β-lactams and β-lactamase inhibitors in intact bacteria. |
| Databáze: | OpenAIRE |
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