Application of enzymic Baeyer–Villiger oxidations of 2-substituted cycloalkanones to the total synthesis of (R)-(+)-lipoic acid

Autor:	Sandrine Pedragosa-Moreau, M. Teresa Bes, Gideon Grogan, Peter W. H. Wan, Stanley M. Roberts, Ray McCague, Andew J. Willetts, Brian Adger, Raffaella Villa
Rok vydání:	1995
Předmět:	chemistry.chemical_classification biology chemistry Stereochemistry Molecular Medicine Organic chemistry Total synthesis (R)-lipoic acid Monooxygenase Optically active biology.organism_classification Pseudomonas putida Lactone
Zdroj:	J. Chem. Soc., Chem. Commun.. :1563-1564
ISSN:	0022-4936
DOI:	10.1039/c39950001563
Popis:	Oxidation of ketones 1a–h using a monooxygenase from Pseudomonas putida NCIMB 10007 gave the lactones 2a–h in optically active form: lactone 2h was converted into (R)-(+)-lipoic acid 9.
Databáze:	OpenAIRE
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