Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology

Autor:	Ernst Küsters, Emil Schmid, Robert Reuille, Géraldine Fuchs, Michel Bailly, Philippe Adam, Roger-Marc Nicoud, Firoz D. Antia
Rok vydání:	1993
Předmět:	Pharmacology Chromatography Scale (ratio) Chemistry Organic Chemistry Epoxide Catalysis Analytical Chemistry chemistry.chemical_compound Cellulose triacetate Adsorption Phase (matter) Drug Discovery Enantiomer Simulated moving bed Moving bed Spectroscopy
Zdroj:	Chirality. 5:267-271
ISSN:	0899-0042
DOI:	10.1002/chir.530050415
Popis:	The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. © 1993 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9efe36c4537a3840b191cd03c07766e3 https://doi.org/10.1002/chir.530050415 Zobrazit plný text záznamu Plný text