The metathesis reaction for side chain construction in carbocyclic sinefungin analogue synthesis

Autor:	Tetyana S. Shulyak, Qi Chen, Chong Liu, Stewart W. Schneller
Rok vydání:	2014
Předmět:	Organic Chemistry Metathesis Biochemistry Combinatorial chemistry Analogue synthesis Carbocyclic sinefungin Grubbs' catalyst Sinefungin chemistry.chemical_compound chemistry Drug Discovery Side chain Salt metathesis reaction Nucleoside
Zdroj:	Tetrahedron. 70:892-900
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.12.030
Popis:	The naturally occurring nucleoside sinefungin has found considerable use in biological investigations. More extensive sinefungin studies have been limited because few analogues have been reported due to the synthetic challenges associated with such studies. Reported herein are preparative ways to two carbocyclic sinefungin analogues: 6′-deaminocarbocyclic sinefungin and (S)-6′-hydroxy-6′-deaminocarbocyclic sinefungin. The synthetic routes were made efficient and practical by the application of two metathesis reactions employing second generation Grubbs catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9ef90237e574525db90449534283dddb https://doi.org/10.1016/j.tet.2013.12.030 Zobrazit plný text záznamu Full Text from ScienceDirect