| Autor: |
Ravindra K. Gupta, Prasanti Kotagiri, James A. Nathan, Stephen Baker, Nicholas J Matheson, Berthold Göttgens, Paul A. Lyons, Natalie Burrows, Mark Toshner, John Bradley, Stephen Moore, Aimee Hanson, Patrick H. Maxwell, Zewen K. Tuong, Rachael Bashford Rogers, Myra Hosmillo, Christoph Hess, Ian Goodfellow, Laura Bergamaschi, Benjamin J. Dunmore, Brian Ortmann, Menna R. Clatworthy, Nathalie Kingston, Lorinda Turner, Kenneth G. C. Smith, Michael P. Weekes, Caroline Saunders, Paul J. Lehner, Hélène Ruffieux, Michael D Morgan, Sylvia Richardson, Anne Elmer, Federica Mescia, Nathan Richoz, Ana Peñalver |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This brought to mind the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19. We demonstrated the breadth of early and persistent defects in B cell subsets in moderate/severe COVID-19, including reduced marginal zone-like, memory and transitional B cells, changes we also observed in B cell VHL-deficient mice. This was corroborated by hypoxia-related transcriptional changes in COVID-19 patients, and by similar B cell abnormalities in mice kept in hypoxic conditions, including reduced marginal zone and germinal center B cells. Thus hypoxia might contribute to B cell pathology in COVID-19, and in other hypoxic states. Through this mechanism it may impact on COVID-19 outcome, and be remediable through early oxygen therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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