Brain SPECT in Sydenham's chorea in remission
| Autor: | Carla Flávia de Lima, Márcio Nattan, Rogério Gomes Beato, Luciane Guerra Boanova, Francisco Cardoso, Cristiano Ferrari Siqueira, Belmonte J. Marroni, Débora Palma Maia |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Putamen Significant difference Sydenham's chorea Chorea medicine.disease Neurology Internal medicine mental disorders Basal ganglia medicine Cardiology Rheumatic fever Neurology (clinical) medicine.symptom Psychology Perfusion Neuroscience Emission computed tomography |
| Zdroj: | Movement Disorders. 29:256-258 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.25721 |
| Popis: | Background Sydenham's chorea, a major manifestation of rheumatic fever, is characterized by chorea, behavioral changes, and cognitive dysfunction. Perfusion changes in the basal ganglia are the most frequent imaging findings observed in patients with Sydenham's chorea. Methods Twelve adult women with Sydenham's chorea in remission underwent brain single-photon emission computed tomography (SPECT). Their scans underwent a quantification process to evaluate the perfusion of Brodmann's areas of the frontal lobes and basal ganglia. The results were compared with the findings from a control group that was matched by age. Results A pattern of hyperperfusion in the left putamen was observed in the patient group (P = 0.02). No significant difference was observed in relation to other brain regions. Conclusions The findings of brain SPECT suggest that perfusion abnormalities of the basal ganglia may persist even after the remission of abnormal movements in patients with Sydenham's chorea. © 2013 International Parkinson and Movement Disorder Society |
| Databáze: | OpenAIRE |
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