P5-23-02: Clinicopathological Features of Young Patients Age <35 Years with Breast Cancer in Japan

Autor: Akemi Kataoka, Takayuki Kinoshita, Eriko Tokunaga, Norikazu Masuda, Tadahiko Shien, Shinji Ohno, Chikako Shimizu
Rok vydání: 2011
Předmět:
Zdroj: Cancer Research. 71:P5-23
ISSN: 1538-7445
0008-5472
Popis: Background: The aim of this study is to clarify clinicopathological features of breast cancer in young women. Materials and methods: Clinicopathological characteristics were compared between young ( Comparison of clinicopathological factors between young and non-young patients with breast cancer Young patients were received more neoadjuvant chemotherapy and breast conserving therapy (BCT), compared with non-young patients. Comparison of treatments between young and non-young patients with breast cancer Eighty-percent of patients were received adjuvant therapy, among them, treatment rate of chemotherapy, molecular targeted therapy and radiation therapy was significantly higher in young patients than non-young patients. There was significant difference in 10-yr OS between young and non-young patients with Stage I-IIIA disease (Stage I 80% vs. 90%, IIA 78% vs. 85%, IIB 67% vs. 78%, IIIA 42% vs. 64%), but not with Stage IIIB and IIIC. Advanced TNM stage, lymph node metastasis and ER-negative tumor were significantly poorer prognostic factors for young patients by univariate analysis. Approximately 9% of young patients were at pregnancy at the time of diagnosis had more advanced disease and worse prognosis. Conclusions: We conclude that young patients with breast cancer have an advanced or an endocrine-unresponsive tumor and have unfavorable outcome. Advocacy for awareness of breast cancer to young women and development of new targeted therapy against advanced, HER2−positve and triple-negative tumor are important to improve the survival of young patients with breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-23-02.
Databáze: OpenAIRE
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