Curcumin Prevents Chromium Induced Sperm Characteristics In Mice
| Autor: | M Mosheraju, K. Rudrama Devi, K Dilip Reddy |
|---|---|
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | IOSR Journal of Pharmacy (IOSRPHR). 2:312-316 |
| ISSN: | 2250-3013 2319-4219 |
| DOI: | 10.9790/3013-0220312316 |
| Popis: | Chromium was discovered in 1797 and found in all phases including air, water, and soil biota. Major uses of hexavalent chromium are metallurgical metal plating leather tanning etc. In spite its uses it has been reporting ITAR 1990 as a potent carcinogen teratogen and mutagen. The clastogenic potential of chromium has been well documented. In contrast to the activity of chromium, curcumin is a yellow colored derived from powdered rhizome Curcuma Longa is useful for the treatment of many disorders inflammation, skin wounds, certain tumors. Hence in the present investigation, studies were carried out to evaluate the protective role of curcumin on chromium induced gentoxicity in germ cells of male mice. In the present study four batches were of animals were maintained. Group II animals were given 60 mg/kg of chromium once in a week, whereas group III mice were given curcumin 5 and 7.5 mg /kg for five weeks. Group IV animals were pretreated with 5 and 7.5 mg/kg curcumin for 5 weeks plus chromium 60mg/kg once in a week. All the animals were sacrificed on the 35 th day and cauda epidymis was processed and slides were screened for the incidence of various types of sperm head abnormalities. A significant increase was observed in chromium treated animals. However when animals pretreated with curcumin, the percentage of sperm characters decreased the significance of two dose levels. Thus the results clearly indicate the protective effect of curcumin against chromium damage in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|