| Popis: |
A Couple of human studies have demonstrated that oral ingestion of collagen peptides improves subjective and objective skin conditions. Animal experiments also have demonstrated that ingestion of collagen peptides attenuates ultra violet irradiation-induced skin damages. On the other hand, it was considered that orally administered peptides were degraded into amino acids during digestion and absorption processes thus did not show special effects beyond amino acid source. However, observations of the presence (μM levels) of hydroxyproline (Hyp)-containing peptides in human blood after ingestion of collagen peptides changed the conventional view on digestion and absorption of these peptides. Pro-Hyp accounts for more than 50% of the total collagen peptides in the blood and enhances number of fibroblasts migrating from skin, proliferation of skin fibroblast on collagen gel, and production of hyaluronic acid. These activities of Pro-Hyp could be associated with the beneficial effects by ingestion of collagen peptides. This mini review summarizes the recent knowledge of the structure, contents, and biological activities of the food-derived collagen peptides present in human blood. Additionally, it discusses the mechanism for the beneficial effects of ingestion of collagen peptides. |
