Cytarabine assures a high concentration of circulating CD34+ cells during haematopoietic stem cells mobilization in lymphoma patients

Autor: Ivo Gentilini, Lucia Canzian, Massimo Daves, Ahmad Al-Khaffaf, Ugo Salvadori, Milena Pintimalli, Roberto Melotti
Rok vydání: 2017
Předmět:
Zdroj: La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine. 13:173-179
ISSN: 2039-6821
1825-859X
Popis: Mobilization of haematopoietic stem cells for autologous transplantation in lymphoma patients currently lacks optimal and universally accepted protocol guidelines. Available mobilization procedures use either cytokines alone, predominantly granulocyte colony-stimulating factor, or cytokines in combination with chemotherapy. Chemomobilization may increase the CD34+ cell yield, and some studies indicate that a higher number of CD34+ cells reinfused is associated with better outcome after autologous haematopoietic stem cells transplantation. We aimed to compare the peak of CD34+ cells in peripheral blood between two alternative mobilization therapies in a retrospective cohort of patients affected by lymphoma. Between 2001–2012, 125 retrospectively observed lymphoma patients were treated with either cytarabine ( $n = 36$ ) or cyclophosphamide ( $n = 89$ ), both combined with granulocyte colony-stimulating factor. The difference in the peak of circulating CD34+ cells was the study primary endpoint. The peak of circulating CD34+ cells were significantly higher in the cytarabine group compared with the cyclophosphamide group (median 129/μL vs 77/μL; $p < 0.05$ ), even when accounting for the timing at collection (169% higher in the cytarabine group, $p < 0.01$ ). Haematopoietic stem cells median time collection started 3 days later in the cytarabine group (16 vs 13 days; $p < 0.01$ ). A leukaphaeresis single session was adequate to collect an optimal number of CD34+ cells (greater than $5 \times 10^{6}/\text{kg}$ ) in 69% patients in the cytarabine group compared with 57% in the cyclophosphamide group ( $p = 0.21$ ). Cytarabine gives a higher peak of circulating CD34+ cells in comparison with cyclophosphamide in a retrospective observational cohort of lymphoma patients submitted to chemomobilization.
Databáze: OpenAIRE
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