Effects of Shin'i-seihai-to and Sho-seiryu-to on Production of Active Oxygen Species by Neutrophils

Autor:	Makiko Babazono, Masaru Ohyama, Shinya Matsunaga, Yoko Imamura, Kazunori Itoh
Rok vydání:	1992
Předmět:	business.industry Kampo education Zymosan Chronic sinusitis Pharmacology In vitro Active oxygen Pathogenesis chemistry.chemical_compound Otorhinolaryngology chemistry Immunology Medicine Dismutase business Opsonin
Zdroj:	Practica Oto-Rhino-Laryngologica. 85:1975-1980
ISSN:	1884-4545 0032-6313
DOI:	10.5631/jibirin.85.1975
Popis:	It has been reported that Shin'i-seihai-to and Sho-seiryu-to, which are Kampo (Chinese herbal) medicines, are effective for sinusitis and nasal allergy, respectively. It has been suggested that excessive active oxygen species are probably involved in the pathogenesis of chronic sinusitis and allergic diseases.In this study, the effect of Shin' i-seihai-to and Sho-seiryu-to on the production of active oxygen species by human neutrophils was investigated with an in vitro luminol-dependent chemiluminescence method and a cytochrome-C reduction method.Neutrophil production of active oxygen species induced by FMLP (formyl-methionyl-leucyl-phenylalanin) was significantly inhibited by Shin' i-seihai-to and Sho-seiryu-to in a dose dependent manner. The inhibition by Shin' i-seihai-to occurred at lower concentration than that by Sho-seiryu-to.Neutrophil production of active oxygen species induced by opsonized zymosan was not changed by Shin'i-seihai-to.Superoxide dismutase activity by Shin'i-seihai-to and Sho-seiryu-to could not be demonstrated by the cytochrome-C reduction method.These results indicate that inhibition of neutrophil production of active oxygen species by Shin'i-seihai-to and Sho-seiryu-to is one of the pharmacological properties of these two Kampo medicines.
Databáze:	OpenAIRE
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