Non-mnestic cognitive function in the scopolamine model of Alzheimer's Disease
| Autor: | Shona Walker, John A. O. Besson, John Robertson Crawford, Marc Obonsawin, L Blackmore, Denis M. Parker, Chris Perera, Anne Robertson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Neuropsychology Judgment of Line Orientation Wechsler Adult Intelligence Scale Cognition Audiology medicine.disease behavioral disciplines and activities Psychiatry and Mental health Neurology Finger tapping medicine Verbal fluency test Dementia Pharmacology (medical) Neurology (clinical) Alzheimer's disease Psychology Neuroscience |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 13:439-449 |
| ISSN: | 1099-1077 0885-6222 |
| DOI: | 10.1002/(sici)1099-1077(199808)13:6<439::aid-hup19>3.0.co;2-e |
| Popis: | The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0.5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale — Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R profile does not have a cholinergic basis. Scopolamine did not impair performance on verbal fluency, the Token Test, Judgment of Line Orientation, finger tapping, the Modified Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. #1998 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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