Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in piglets
| Autor: | Jon-Kenneth Heltne, T. Lund, M.-E. Koller, Paul Husby, Joel L. Bert, M. Farstad, S. E. Rynning |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Oncotic pressure
medicine.diagnostic_test business.industry Blood volume General Medicine Hypothermia Hematocrit Hemoconcentration law.invention surgical procedures operative Anesthesiology and Pain Medicine law Interstitial fluid Anesthesia Blood plasma Cardiopulmonary bypass Medicine medicine.symptom business circulatory and respiratory physiology |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 45:720-728 |
| ISSN: | 0001-5172 |
| Popis: | Background: Hypothermia, commonly used for organ protection during cardiopulmonary bypass (CPB), has been associated with changes in plasma volume, hemoconcentration and microvascular fluid shifts. Fluid pathophysiology secondary to hypothermia and the mechanisms behind these changes are still largely unknown. In a recent study we found increased fluid needs during hypothermic compared to normothermic CPB. The aim of the present study was to characterize the distribution of the fluid given to maintain normovolemia. In addition, we wanted to investigate the quantity and quality of the fluid extravasated during hypothermic compared to normothermic CPB. Methods: Two groups of anesthetized piglets were studied during 2ho fhypothermic (28 aeC) (n‰7) or normothermic (38 aeC) (n‰7) CPB. Net fluid balance (input»output) was recorded. Changes in colloid osmotic pressures of plasma (COPp) and interstitial fluid (COPi), plasma volume (PV), hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), s-osmolality, s-albumin and s-total protein was followed throughout the experiments. Fluid extravasation rate was calculated. In addition, total tissue water content was measured and compared with a control group (n‰6) (no CPB). Results: During hypothermic compared with normothermic CPB, the average net positive fluid balance from 10‐120 min of |
| Databáze: | OpenAIRE |
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