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Independent senior housing is a high risk setting for COVID-19 and should be prioritized for outbreak investigation and response. During a COVID-19 outbreak in Massachusetts from December 2021 to January 2022, 47% of residents in a 31-unit independent senior housing apartment building in Massachusetts were infected. Residents that had received a booster dose of an mRNA COVID-19 vaccine had a lower attack rate than those who had received two doses. Comprehensive response campaigns that include education, testing, treatment referrals, and vaccination can be effective at reducing morbidity and mortality and preventing future outbreaks. |