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ObjectiveA systematic review with meta-analysis was performed to assess a possible association between plasma vitamin D levels and mortality in patients with COVID – 19.MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Studies involving COVID-19 patients that reported an association between plasma vitamin D levels and COVID-19 mortality published until February 5, 2021, were included. The risk ratio (RR) and confidence interval (CI) were pooled using a fixed-effects or random-effects model.ResultsA total of 11 studies that measured plasma vitamin D levels at admission were included in the meta-analysis, ten cohorts and one case-controls. Low plasma vitamin D levels (25(OH)D) in patients with COVID-19 were not associated with mortality (RR=1.35, 95%CI 0.84–1.86). Subgroup analysis by vitamin D cut-off (ConclusionDeficient vitamin D levels were not associated with a higher mortality rate in patients with COVID-19. Randomized clinical trials are needed to assess this association. |
