The usefulness of copeptin for the diagnosis of nephrogenic diabetes insipidus in infancy: a case report
| Autor: | Juliana Lacerda de Oliveira Campos, Ana Cristina Simões e Silva, Stephanie Bruna Camilo Soares de Brito, Beatriz Santana Soares, Bruna Luisa Fischer, Letícia Bitencourt, Carolina Mazieiro Versiani, Pedro Alves Soares Vaz de Castro, Juliana B. Drummond |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Gold standard Copeptin Measurement 030209 endocrinology & metabolism Case presentation medicine.disease Nephrogenic diabetes insipidus 03 medical and health sciences Pediatric patient 0302 clinical medicine Endocrinology Increased risk Copeptin Pediatrics Perinatology and Child Health Medicine 030212 general & internal medicine Hypernatremia business |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 34:1475-1479 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Objectives We report a case of an infant with nephrogenic diabetes insipidus (NDI) diagnosed by the measurement of serum copeptin. There is only one study that previously evaluated the use of copeptin measurement in a pediatric patient. Case presentation We present a 10-month-old child with polyuria–polydipsia syndrome (PPS) and hypernatremia that could not support water restriction due to increased risk of dehydration and worsening of his condition. Therefore, plasma measurement of copeptin allowed the diagnosis of NDI. Conclusions The water deprivation test (WDT) is considered the gold standard for diagnosis in PPS. However, WDT has serious limitations regarding its interpretation. Furthermore, the WDT can cause dehydration and hypernatremia, especially in young children. Therefore, the measurement of plasma copeptin seems to be a promising method to perform an earlier, safer, and accurate investigation of PPS. Up to now, our study is the second to report the usefulness of copeptin in children. |
| Databáze: | OpenAIRE |
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