Molecular mechanisms of antitumor activity of the polymeric form of niclosamide with respect to human colorectal cancer cells
| Autor: | E. Yu. Moskaleva, Yu. P. Semochkina, A. S. Zhirnik, E. A. Vorontsov, N. I. Krylov, I. A. Tubasheva, S. L. Kuznetsov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Reactive oxygen species Clinical Biochemistry Cell cycle Pharmacology Biology Biochemistry Rhodamine 123 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Cell culture 030220 oncology & carcinogenesis Cancer cell Cancer research medicine Molecular Medicine Cytotoxic T cell Niclosamide Intracellular medicine.drug |
| Zdroj: | Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 11:301-307 |
| ISSN: | 1990-7516 1990-7508 |
| Popis: | Using poly(lactic-co-glycolic) acid a polymeric form of niclosamide (PFN) has been developed and its antitumor activity against human colorectal cancer cell lines SW837, Caco-2, COLO 320 HSR has been investigated in comparison with free niclosamide. PFN was shown to be more cytotoxic against cancer cells and less cytotoxic against normal cells (human embryonic lung fibroblasts) as compared to niclosamide. Free niclosamide and PFN share a common mechanism of the cytotoxic action on tumor cells, which is associated with mitochondrial damage (evaluated as a decrease in rhodamine 123 accumulation), and increased levels of reactive oxygen species, particularly mitochondrial superoxide anion, causing oxidative damage of intracellular targets. The action of niclosamide and PFN was accompanied by G0/G1 cell cycle arrest. |
| Databáze: | OpenAIRE |
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