Pennigritrem, a naturally-occurring penitrem A analogue with novel cyclisation in the diterpenoid moiety

Autor:	John N. Bilton, Richard N. Sheppard, Peter G. Mantle, Jeremy R. Biddle, Julia Penn
Rok vydání:	1992
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Penitrem A Moiety Biological activity Nuclear magnetic resonance spectroscopy Terpenoid Isoprene
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :23
ISSN:	1364-5463 0300-922X
Popis:	A prominent novel analogue of penitrem A has been resolved from the tremorgenic alkaloids of a strain of Penicillium nigricans and the structure, elucidated by NMR spectroscopy, shown to involve the terminal diterpenoid isoprene in a cyclisation which is unique amongst fungal indolediterpenoids. Consequent conformational changes in the biologically active moiety significantly reduced tremorgenicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e89db2b36fc6a26fd6af0934f7fcb18 https://doi.org/10.1039/p19920000023 Zobrazit plný text záznamu