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Diabetic kidney disease (DKD) is a microvascular complication of progressive renal decline in patients with diabetes, which is the leading cause of end-stage renal disease (ESRD) globally. Early epidemiological and genetic studies demonstrated that DKD is a heritable condition, indicative of an underlying genetic component for its increased susceptibility. Since then, significant work has been conducted to unravel causal genes implicated in DKD development and progression. With the advancement of genomic technologies, genome-wide association studies (GWASs) and next-generation sequencing (NGS) approaches continue to expand our knowledge of the genetic architecture of DKD and uncover novel biological pathways implicated in disease pathogenesis. Additionally, the establishment of large international collaborations has led to significantly increased cohort sizes to improve overall statistical power to detect novel associations. |
