Imaging ofpHandpO2gives insight in molecular processes of irradiated cells

Autor:	Gregor Liebsch, Lukas Prantl, Stephan Schreml, Fabian Pohl, Yvonne Reinders, Frank Haubner, Robert J. Meier
Rok vydání:	2019
Předmět:	0301 basic medicine Cell type Chemistry medicine.medical_treatment chemistry.chemical_element Dermatology Biochemistry Oxygen In vitro Squamous carcinoma Radiation therapy 030207 dermatology & venereal diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Biophysics medicine Irradiation Wound healing Fibroblast Molecular Biology
Zdroj:	Experimental Dermatology. 28:628-630
ISSN:	1600-0625 0906-6705
DOI:	10.1111/exd.13905
Popis:	One of the major challenges in radiation therapy is the interference with tissue repair processes due to hypoxic characteristics and pH dysregulation. In this study, we present dual imaging of pH and oxygenation in vitro based on luminescent biocompatible sensor foils that allow studying the effects of irradiation on different cell types in culture. Different sensitivities of fibroblast and oral squamous carcinoma cells were observed by complementing oxygen and pH differences with proliferation assays. This study highlights especially the distinct role of oxygen after irradiation and the difference in proliferation processes of irradiated normal dermal cells in contrast to irradiated tumor cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e791f8426bf5586c0f748ef96b88d84 https://doi.org/10.1111/exd.13905 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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