Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents

Autor:	M. S. R. Murty, Nishant Jain, Pompi Das, Raju Penthala, Sudheer Kumar Buddana, Sowjanya Polepalli, Reddy Shetty Prakasham, Sreedhar Bojja
Rok vydání:	2014
Předmět:	Antifungal Chemistry medicine.drug_class Organic Chemistry Pharmacology toxicology Combinatorial chemistry In vitro Cuo nanoparticles Catalysis Antiproliferative Agents medicine Organic chemistry General Pharmacology Toxicology and Pharmaceutics IC50
Zdroj:	Medicinal Chemistry Research. 23:4579-4594
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-014-1025-x
Popis:	A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C–O coupling by direct C–H bond activation of N-aroyl-N-arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compounds have been synthesized in good to excellent yields (75–90 %). All the synthesized compounds were evaluated for their in vitro antiproliferative, antibacterial, and antifungal activity. Compounds 8d and 10d are more promising antiproliferative agents with IC50 value of 3.66 and 3.89 µM in MCF-7 cell line, and compounds 8a and 10a were showed more potent antifungal activity than standard drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e7439fbf337b8c834332a7b86846b85 https://doi.org/10.1007/s00044-014-1025-x Zobrazit plný text záznamu Full text from SpringerLink