Characterization of the Production of Acetaldehyde by Astrocytes in Culture after Ethanol Exposure

Autor:	G. Bessard, B. Gonthier, H. Eysseric, A. Soubeyran, Luc Barret, R. Saxod
Rok vydání:	1997
Předmět:	Ethanol Central nervous system Acetaldehyde Neurotoxicity Medicine (miscellaneous) Biological activity Biology Toxicology medicine.disease Psychiatry and Mental health chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry Cell culture Toxicity medicine Astrocyte
Zdroj:	Alcoholism: Clinical and Experimental Research. 21:1018-1023
ISSN:	1530-0277 0145-6008
Popis:	The nervous system is one of the main targets of ethanol toxicity. Astrocytes might play an important role in ethanol-induced brain toxicity, because their integrity is essential for the normal growth and functioning of neurons. On the other hand, acetaldehyde has been implicated as a mediator in some of the biochemical, pharmacological, and behavioral effects of ethanol. The present study aimed at demonstrating the ability of astrocytes in culture to produce acetaldehyde from ethanol. Significant metabolization of ethanol with production of acetaldehyde was demonstrated in the primary culture of astrocytes. This production was quite low, compared with that usually observed in hepatocytes, but was in the same range as that measured in whole brain homogenates and corresponded to biologically active levels. Such a demonstration could bring new elements for understanding of ethanol neurotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e6f8e12373fcdbf078783579d0335c7 https://doi.org/10.1111/j.1530-0277.1997.tb04247.x Zobrazit plný text záznamu Plný text