Beta Cell Regenerating Potential of Azadirachta indica (Neem) Extract in Diabetic Rats
| Autor: | O Parshad, Garsha McCalla, Paul D. Brown, Michael T. Gardner |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
geography
medicine.medical_specialty geography.geographical_feature_category biology business.industry Insulin medicine.medical_treatment General Medicine Azadirachta medicine.disease Islet Streptozotocin biology.organism_classification medicine.anatomical_structure Endocrinology Diabetes mellitus Internal medicine medicine Beta cell medicine.symptom Pancreas business Weight gain medicine.drug |
| Zdroj: | West Indian Medical Journal. |
| ISSN: | 0043-3144 |
| DOI: | 10.7727/wimj.2014.224 |
| Popis: | Objective This study evaluated the ability of 0.8% neem leaf extract (NLE) to treat diabetes mellitus by assessing its effects on blood glucose, insulin levels and islet morphology in streptozotocin (STZ)-induced diabetic Sprague-Dawley rats. Methods Diabetes was induced in two to three-day old rat pups by STZ intraperitoneally (60 mg/kg), followed by a further 40 mg/kg dose 12-23 weeks later. The diabetic treated (DT) rats received 0.8% w/v NLE in tap water while diabetic control (DC) and normal control (NC) rats received water ad libitum. Body weight, water and chow consumption, and blood glucose were evaluated weekly. Blood and pancreas were collected at the end of the study to evaluate serum insulin and islet histology, respectively. Results Neem leaf extract (0.8%) improved weight gain and beta cell regeneration but did not reduce blood glucose. Serum insulin increased slightly in the treated group and three-fold in the DC group (p < 0.05). Conclusion The results suggest that NLE has beta cell regenerating potential. |
| Databáze: | OpenAIRE |
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