Kinetic study of the chlorine transfer fromN-chlorosuccinimide to amino compounds
| Autor: | F. Arce, M. Paraj, J. Crugeir, J. M. Antelo |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Reaction mechanism Sarcosine fungi Organic Chemistry Inorganic chemistry Medicinal chemistry humanities Pyrrolidine Amino acid Reaction rate chemistry.chemical_compound Reaction rate constant chemistry Ionic strength Amine gas treating Physical and Theoretical Chemistry |
| Zdroj: | Journal of Physical Organic Chemistry. 10:631-636 |
| ISSN: | 1099-1395 0894-3230 |
| DOI: | 10.1002/(sici)1099-1395(199708)10:8<631::aid-poc924>3.0.co;2-w |
| Popis: | A kinetic study of the reactions of N-chlorosuccinimide (NCS) with glycine (Gly), sarcosine (Sar), 2-methylalanine (2MA), proline (Pro) and pyrrolidine (Pyr) was carried out. The reactions were found to be first order with respect to both NCS and the amine or amino acid and order −1 in proton concentration. In order to calculate the experimental activation parameters, the effect of temperature on the reaction rates was studied. The ionic strength and buffer concentration were found to have no effect on the rate constant. A reaction mechanism involving Cl+ transfer from NCS to the amine or amino acid to form an N-chloro compound is proposed © 1997 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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