The Preparation of Substituted 1(2H)-Isoquinolinones from Dilithiated 2-Methyl-N-arylbenzamides, 2-Methyl-N-(arylmethyl)-benzamides, or 2-Methylbenzoic Acid, 2,2-Dimethylhydrazide

Autor:	A. Cameron Church, Sharon E. Davis, Charles F. Beam, Cynthia L. Mazat Griffith
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Organic chemistry 2-methylbenzoic acid Lithium diisopropylamide
Zdroj:	Synthetic Communications. 27:2961-2969
ISSN:	1532-2432 0039-7911
Popis:	2-Methyl-N-arylbenzamides (N-aryl-ortho-toluamides), 2-methyl-N-(arylmethyl)-benzamides (substituted benzyl, N-benzyl-ortho-toluamides), or 2-methylbenzoic acid, 2,2-dimethylhydrazide (ortho-toluic acid, N,N-dimethylhydrazide), were dilithiated with excess lithium diisopropylamide, and the resulting polyanion-type intermediates were condensed with aromatic esters followed by acid cyclization to the 3-substituted-1(2H)-isoquinolinones (isocarbostyrils).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e42a83a6d3ff5cbcfed79aae2f564db https://doi.org/10.1080/00397919708005002 Zobrazit plný text záznamu