The first rigid anion capped β-cyclodextrin for the effective inclusion binding of hydrophobic cationic molecules

Autor:	Tatsushi lkeji, Iwao Tabushi, Tatsuya Nabeshima, Kazuo Yamamura, Hidetaka Shinkai
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Cyclodextrin Stereochemistry Organic Chemistry Cationic polymerization macromolecular substances Biochemistry Inclusion compound chemistry.chemical_compound Sulfonate chemistry Amide Drug Discovery Polymer chemistry Lactam Moiety Titration
Zdroj:	Tetrahedron Letters. 31:7017-7020
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)97231-9
Popis:	A new member of capped-β-cyclodextrin, phenanthridinone-2,9-disulfonate cap (1), has been prepared. The amide NH proton of the capping moiety was found to dissociate into amide-N− anion with pKa=11.2 based on the results of UV-VIS titration, providing for the first time an anionic charged cap above pH 12 to bind cationic guests effectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e413ed8439e4cb47df3fa6be73d0e78 https://doi.org/10.1016/s0040-4039(00)97231-9 Zobrazit plný text záznamu