Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis
| Autor: | James D. Miller, Judith D. Knittle, JM Wheeler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Danazol
medicine.medical_specialty Chemotherapy medicine.diagnostic_test business.industry Depot medicine.medical_treatment Endometriosis Urology Obstetrics and Gynecology medicine.disease Surgery law.invention Clinical trial Randomized controlled trial Multicenter study law medicine business Laparoscopy hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 167:1367-1371 |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: We aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis. STUDY DESIGN: A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods. RESULTS: When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis. CONCLUSION: Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain. |
| Databáze: | OpenAIRE |
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