Abstract 5379: Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthetase 1 Impairs Mitochondrial Function and Dynamics

Autor:	Heiko Bugger, Xiao Xuan Hu, Joseph Tuinei, Heather Theobald, William L Holland, Genevieve Sparagna, Scott A Summers, Jean E Schaffer, E. Dale Abel
Rok vydání:	2008
Předmět:	Physiology (medical) Cardiology and Cardiovascular Medicine
Zdroj:	Circulation. 118
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.118.suppl_18.s_538-a
Popis:	Increased uptake and oxidation of fatty acids (FA) in diabetic hearts may contribute to mitochondrial dysfunction by promoting oxidative stress. To test this hypothesis, we investigated mice with cardiomyocyte-restricted overexpression of long-chain acyl-CoA synthetase 1 (MHC-ACS). In vivo PET studies revealed increased myocardial FA uptake (+120%; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e32930cafba54697dd0834b87a5da4f https://doi.org/10.1161/circ.118.suppl_18.s_538-a Zobrazit plný text záznamu