Anisocoria producida por bupropión en paciente migrañosa
| Autor: | Miguel A. Teus, Consuelo Gutiérrez-Ortiz, Vleming En |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Gynecology
Bupropion medicine.medical_specialty Anisocoria business.industry Physiological anisocoria Horner syndrome Migraine Disorders medicine.disease Ophthalmology health services administration mental disorders behavior and behavior mechanisms medicine Mydriasis Personal history medicine.symptom business medicine.drug |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología. 82 |
| ISSN: | 0365-6691 |
| DOI: | 10.4321/s0365-66912007000800014 |
| Popis: | espanolIntroduccion: El bupropion se usa como deshabituante del habito tabaquico. Puede provocar alteraciones visuales, pero hasta el momento no se habia comunicado la aparicion de anisocoria. Caso clinico: Mujer de 40 anos con migranas, en tratamiento con bupropion presento midriasis monocular. Instilando cocaina al 5%, ambas pupilas dilataron de la misma manera. Con pilocarpina 0,025% ambas pupilas contrajeron de forma similar. La anisocoria ceso al suspender el tratamiento. Discusion: El bupropion es inhibidor selectivo de la recaptacion de noradrenalina y dopamina. La via pupilar simpatica podria tener una cierta hipersensibilidad en pacientes migranosos por denervacion que podria estimularse con el tratamiento con estos farmacos, lo que explicaria la anisocoria. Por otra parte el estimulo midriatico del bupropion podria haber desenmascarado una anisocoria fisiologica. EnglishIntroduction: Bupropion is used to help people stop smoking. This drug can cause visual alterations but, up to now, its use was not associated with anisocoria. Case report: A 40 year-old woman with a personal history of migraines, presented with monocular mydriasis during treatment with bupropion. Both pupils dilated equally after a 5% cocaine test, and constricted equally after a 0.025% Pilocarpine test. The anisocoria disappeared after the treatment with bupropion was withdrawn. Discussion: Bupropion inhibits neural uptake of norepinephrine and dopamine. Patients with migraine could have a minor unilateral sympathetic pupillary deficit. This deficit could cause hypersensitivity in the oculosympathetic pathway that could be stimulated with bupropion treatment. This feature could explain the mydriasis in our patient. Another explanation could be that bupropion could unmask a physiological anisocoria |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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