Lower Extremity Ischemia, Calf Skeletal Muscle Characteristics, and Functional Impairment in Peripheral Arterial Disease
| Autor: | Leena Sharma, Lu Tian, Frederick L. Hoff, William H. Pearce, Mary M. McDermott, Michael H. Criqui, Joseph R. Schneider, Kiang Liu, Jack M. Guralnik, Luigi Ferrucci, Jin Tan |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
business.industry Vascular disease Ischemia Skeletal muscle medicine.disease Intermittent claudication Surgery body regions medicine.anatomical_structure Blood pressure Internal medicine Sarcopenia medicine Cardiology Geriatrics and Gerontology Ankle medicine.symptom Claudication business |
| Zdroj: | Journal of the American Geriatrics Society. 55:400-406 |
| ISSN: | 1532-5415 0002-8614 |
| Popis: | Although it is known that patients with lower extremity peripheral arterial disease (PAD) have greater functional impairment and faster rates of functional decline than persons without PAD,1,2 mechanisms of functional impairment and decline in PAD are not well established. Ischemia-related pathological changes in calf skeletal muscle may contribute to functional impairment in patients with PAD, but associations between lower extremity ischemia, calf muscle characteristics, and lower extremity functioning in PAD are not well understood. The purpose of this study was to determine whether participants with lower ankle brachial index (ABI) levels have lower calf skeletal muscle area and greater calf muscle percentage fat than participants with higher ABI levels. Associations between calf muscle area and calf muscle percentage fat and the degree of functional impairment in persons with PAD were also evaluated. |
| Databáze: | OpenAIRE |
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