| Autor: |
Jean-Michel Escoffre, Lydie Nadal-Desbarats, Anaïs Millet, Antoine Presset, Patrick Emond, Edward Oujagir, Antoine Lefèvre, Ayache Bouakaz, Sylvie Bodart |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
The Journal of the Acoustical Society of America. 149:A119-A119 |
| ISSN: |
0001-4966 |
| DOI: |
10.1121/10.0004711 |
| Popis: |
In this study, rats' right striata were exposed to microbubble-assisted ultrasound in order to open the BBB. This work aimed to investigate the metabolic consequences of this process on rat's serum and cerebrospinal fluid using the 1H-NMR spectroscopy study. The biochemical analysis of CSF and serum metabolomes indicated significant changes in several metabolic pathways related to alternative sources of cellular energetic metabolism, immediately and up to 48 h after the BBB opening. These findings could highlight the implication of hypoxia-associated processes into the BBB opening or the modulation of neurotransmission. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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