A case of spontaneous true hermaphroditism in the rat with evidence of female character

Autor:	Masashi Yasuba, Kazuo Okimoto, Yoshiki Terada, Yoshimasa Okazaki, Hideo Nakamura
Rok vydání:	1993
Předmět:	medicine.medical_specialty Ovotestis urogenital system Uterus Uterine horns Biology Toxicology medicine.disease Pathology and Forensic Medicine Endocrinology medicine.anatomical_structure Hermaphrodite Internal medicine Toxicity medicine True hermaphroditism Vagina Oviduct
Zdroj:	Journal of Toxicologic Pathology. 6:251-256
ISSN:	1881-915X 0914-9198
DOI:	10.1293/tox.6.251
Popis:	Spontaneous true hermaphroditism in a rat is reported. This animal was a unilateral hermaphrodite composed of a testis on the left and an ovotestis on the right, although the external genitalia was masculine. In the present case, there were epididymides and vasa deferentia on both sides, an oviduct and a uterine horn on the right side, and seminal vesicles dorsal to the uterus, but prostate glands and the external orifice of vagina were absent. The ovotestis, unlike the other cases of hermaphroditic rats, was composed of a predominant ovarian tissue and a small area of testicular tissue. The present animal died by a single administration, i.e. the first administration in a repeated dose oral toxicity study, of a test compound having sex difference in the lethal toxicity. The dose given to the animal is expected to cause lethal effects in females but not in males, and the sex difference is presumed to depend on the different activity of S-oxidation by cytochrome P-450, the drug-metabolizing exzyme of the liver. These matters suggest that this animal had been enzymatically female.
Databáze:	OpenAIRE
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