Autor: T. G. Sambandan, Samuel H. Yalkowsky, Bryan D. Tarr
Rok vydání: 1987
Předmět:
Zdroj: Pharmaceutical Research. :162-165
ISSN: 0724-8741
DOI: 10.1023/a:1016483406511
Popis: Taxol (NSC-125973) is a poorly soluble plant product that exhibits excellent antimitotic properties. This study involves the development of a new formulation for taxol. The stability of taxol in a 50% triacetin emulsion as well as possible methods of intravenous administration of this dosage form was examined. A stable emulsion was found at taxol concentrations of 10 and 15 mg/ml of emulsion. The 50% triacetin emulsion showed an intravenous LD50 of 1.2 ml/kg in Swiss-Webster mice. The 10 mg/ml taxol formulation was demonstrated to be stable upon addition to 5% dextrose iv fluids provided that small packing systems were used. The taxol–triacetin emulsion can also be intravenously injected at various rates, and it may prove to be a useful formulation for taxol.
Databáze: OpenAIRE
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