Partialsynthesen von Cardenoliden und Cardenolid-Analogen. VIII. Lactonring-alkylierte Cardenolide

Autor:	Kurt R. H. Repke, Barbara Streckenbach, H. J. Portius, Rainer Hintsche, Peter Franke
Rok vydání:	1983
Předmět:	chemistry.chemical_classification Allyl chloride Allyl bromide Digitoxin Stereochemistry Chemistry Alkylation Digitoxigenin chemistry.chemical_compound Bromide medicine Cardenolide Lactone medicine.drug
Zdroj:	Journal f�r Praktische Chemie. 325:599-606
ISSN:	1521-3897 0021-8383
DOI:	10.1002/prac.19833250409
Popis:	Partial Syntheses of Cardenolides and Cardenolide Analogues. VIII. Lactone Ring-Alkylated Cardenolides Base-catalyzed alkylation of digitoxigenin (1), digitoxin (2), digoxigenin (3), and gitoxigenin-3,16-diacetate (4) with allyl bromide, allyl chloride or n-propyl bromide in DMF resulted in the formation of the 22-allyl-, 21ξ,22-diallyl-, 22-propyl-, and 21ξ,22-dipropyl-derivatives 5–14, respectively. The determination of the molecular biological activity of the derivatives yielded valuable information.
Databáze:	OpenAIRE
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