Anti-Idiotypic Antibody in Rat Transplantation Immunity
| Autor: | T. J. McKearn, F. P. Stuart, F. W. Fitch |
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| Rok vydání: | 1974 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 113:1876-1882 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.113.6.1876 |
| Popis: | Lewis × Brown Norway (LBN) F1 antiserum to an idiotype of Lewis anti-BN alloantibody (referred to as the Id-1 idiotype) was used to test a variety of Lewis alloimmune sera for the presence of Id-1. Several such Lewis sera raised by BN antigen injection at monthly intervals possessed the Id-1 idiotype. Hyperimmune Lewis anti-BN alloantiserum raised by six weekly injections of BN antigen, however, did not possess the Id-1 idiotype, but appeared to possess anti-idiotypic antibody to Id-1 instead. The anti-BN hemagglutinin titer, anti-idiotypic antibody titer to Id-1, and levels of the Id-1 idiotype were then measured in individual weekly serum samples from Lewis rats repeatedly immunized with BN antigen. The anti-BN hemagglutinin titers followed a cyclical pattern, with the Id-1 idiotype predominating only in the first cycle of the anti-BN hemagglutinin response. Anti-idiotypic antibody was demonstrable in five of eight repeatedly immunized rats, and in each of these five animals the appearance of anti-idiotypic antibody to Id-1 followed the clearance of Id-1 from the serum. Anti-idiotypic antibody may play a role in the regulation or control of an established immune response. |
| Databáze: | OpenAIRE |
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