An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

Autor:	Pranoti A. Tilak, Magali B. Hickey, Mark A. Oliveira, Renato A. Chiarella, Tarek A. Zeidan, Jacob T. Trotta, Bruce M. Foxman, Orn Almarsson
Rok vydání:	2016
Předmět:	010405 organic chemistry Chemistry General Chemistry Crystal structure 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences Anhydrous medicine Organic chemistry General Materials Science Seeding Aripiprazole Active metabolite medicine.drug
Zdroj:	CrystEngComm. 18:1486-1488
ISSN:	1466-8033
DOI:	10.1039/c5ce02467f
Popis:	A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9ddc2b06e71bbaf38b9bbf94caf7b08a https://doi.org/10.1039/c5ce02467f Zobrazit plný text záznamu