Using Mean Field Theory to Guide Biofunctional Materials Design
| Autor: | Katja Schneider, Andrea Zieris, Uwe Freudenberg, Marina Prewitz, Ron Dockhorn, Jens-Uwe Sommer, Silvana Prokoph, Carsten Werner, Karolina Chwalek, Petra B. Welzel, Kandice R. Levental |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Materials science Rational design Nanotechnology Polymer Materials design Condensed Matter Physics Electronic Optical and Magnetic Materials Biomaterials chemistry.chemical_compound Mean field theory chemistry Excluded volume Self-healing hydrogels Electrochemistry Ethylene glycol |
| Zdroj: | Advanced Functional Materials. 22:1391-1398 |
| ISSN: | 1616-3028 1616-301X |
| DOI: | 10.1002/adfm.201101868 |
| Popis: | Cell-instructive characteristics of extracellular matrices (ECM) resulting from a subtle balance of biomolecular and biophysical signals must be recapitulated in engineered biomaterials to facilitate regenerative therapies. However, no material explored so far allows the independent tuning of the involved molecular and physical cues due to the inherent correlation between biopolymer concentration and material properties. Addressing the resulting challenge, a rational design strategy for ECM-inspired biohybrid hydrogels based on multi-armed poly(ethylene glycol) and heparin, adapting a mean field approach to identify conditions at which the balance of elastic, electrostatic, and excluded volume forces results in constant heparin concentrations within swollen polymer networks with gradually varied physical properties is introduced. Applying heparin-based biofunctionalization schemes, multiple distinct combinations of matrix parameters could be identified to effectively stimulate the pro-angiogenic state of human endothelial cells and the differentiation of human mesenchymal stem cells. The study demonstrates the power of joint theoretical and experimental efforts in creating bioactive materials with specifically and independently controllable characteristics. |
| Databáze: | OpenAIRE |
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