Dose-related effects of motilin on proximal gastrointestinal motility

Autor:	Adam F. Cohen, Ad A.M. Masclee, H. C. Schoemaker, Ingrid M. C. Kamerling, Richard Jones, A. D. Van Haarst, Izak Biemond, J. Burggraaf
Rok vydání:	2002
Předmět:	medicine.medical_specialty Hepatology Gastric emptying business.industry Stomach digestive oral and skin physiology Gastroenterology Peptide hormone Crossover study digestive system diseases Motilin Contractility medicine.anatomical_structure Endocrinology Gastrointestinal hormone Internal medicine Medicine Pharmacology (medical) business Antrum hormones hormone substitutes and hormone antagonists
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:129-135
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01142.x
Popis:	Aim: To assess non-invasively the dose–response relations for the effects of exogenous motilin on antrum contraction frequency, gall-bladder volume and gastric myoelectrical activity. Methods: In a double-blind, randomized, placebo-controlled, five-way crossover study, 10 fasted healthy volunteers were infused intravenously with synthetic human motilin (0.5, 1, 2 and 4 pmol.min/kg) or placebo for 60 min. Gall-bladder volume and antrum contractions were assessed by ultrasonography and gastric myoelectrical activity by electrogastrography. Motilin concentrations were measured using a radioimmunoassay. Results: Baseline plasma motilin levels (60 pmol/L) were similar for all treatments. Motilin levels increased upon the start of infusion and rapidly returned to baseline after cessation of the infusion. At motilin doses of 2 and 4 pmol.min/kg, the antrum contraction frequency was significantly augmented, with maximum differences of two contractions per 2-min interval compared to placebo, while no changes in gastric myoelectrical activity were observed. Changes in gall-bladder volume were not significantly different for any of the motilin doses compared to placebo. Conclusions: Motilin increased antrum contraction frequency, whereas no effect on gastric myoelectrical activity was observed. Antrum contraction frequency appears to be a useful biomarker for motilin efficacy, and motilin doses of 2 and 4 pmol.min/kg were equally effective.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9dc7e9d8102bce91d8c35c9ef9b45cfb https://doi.org/10.1046/j.1365-2036.2002.01142.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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