A Facile Route to Substituted Dimethoxy Phosphonothionates Using Dimethyl Thiophosphite

Autor:	Charles M. Thompson, Pakamas Tongcharoensirikul, Jeffrey Trautmann, Alírica I. Suárez, Gregory W. Muth
Rok vydání:	2002
Předmět:	Inorganic Chemistry Dimethyl thiophosphite Chemistry Organic Chemistry Electrophile Dimethyl phosphite Alkylation Biochemistry Medicinal chemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 177:471-477
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500210253
Popis:	Dimethyl thiophosphite reacts with aliphatic aldehydes and ketones, Michael acceptors, and N-benzyl imines to afford excellent yields of f -hydroxy phosphonothionates, g -substituted phosphonothionates and f -amino phosphonothionates, respectively. Dealkylation of f -amino phosphonothionates affords N-benzyl f -amino phosphonothioic acids. Dimethyl thiophosphite reacts with electrophiles at a significantly greater rate than dimethyl phosphite.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9dba4bc168920ef53aac8e4cd1579ed4 https://doi.org/10.1080/10426500210253 Zobrazit plný text záznamu