| Autor: |
T. Alati, M. Coppola, V. Di Majo, C. Bangrazi, Anna Saran, B. Bassani, S. Rebessi, Vincenzo Covelli |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
JNCI: Journal of the National Cancer Institute. |
| ISSN: |
1460-2105 |
| DOI: |
10.1093/jnci/76.5.955 |
| Popis: |
Transplantation of harderian gland cells from CBA/-Cne mice into the fat pad of isogenic recipients was used for a quantitative in vivo study of cell survival and risk of transformation after x-ray irradiation (1-7 Gy). A survival curve for gland cells was generated in vivo with a D0 of 1.83 Gy and an extrapolation number of 7.23. Subsequently, the dose-response curve for lesions observed in nodules after cell transplantation was compared with that for lesions observed in glands irradiated in situ. A high incidence of epithelial hyperplasias with severe dysplasia was observed in transplantation nodules after x-irradiation. Gland tumors were significantly induced in whole-body irradiated animals; the tumors reached a maximum incidence after doses of 3 Gy. The risk of transformation per surviving cell was estimated both for dysplastic lesions and for tumors. These results approximated a dose-squared relationship in both cases, suggesting a common induction mechanism at the cellular level. Myeloid leukemia was observed at all doses in whole-body irradiated mice, and the maximum tumor incidence was reached at doses around 3 Gy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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