Physicochemical Properties and Structure of the Bone Matrix in Simulated Tuberculous Osteitis

Autor:	O. N. Musskaya, V. V. Kazbanov, N. M. Chekan, M. S. Serdobintsev, K. V. Skrotskaya, V. K. Krut’ko, A. A. Gaidash, A. I. Kulak
Rok vydání:	2019
Předmět:	010302 applied physics Physics and Astronomy (miscellaneous) Chemistry Scanning electron microscope chemistry.chemical_element Crystal growth Crystal structure Calcium 01 natural sciences 010305 fluids & plasmas Amorphous solid law.invention Chemical engineering law 0103 physical sciences Bone Trabeculae Electron microscope Thermal analysis
Zdroj:	Technical Physics. 64:121-126
ISSN:	1090-6525 1063-7842
Popis:	The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we revealed that tuberculous osteitis causes fine disintegration of the bone matrix due to an increase in nonstoichiometric hydroxyapatite, formation of amorphous calcium phosphates, and a decrease of the organic phase, which is accompanied by embrittlement of the bone matrix. Excessive growth of carbonate-hydroxyapatite crystals of a mixed AB substitution type leads to excessive osteogenesis, accompanied by the uncontrolled growth of bone trabeculae. The presence of “liming” regions in the crystal lattice of hydroxyapatite increases the “binding” properties of the bone matrix in which mycobacteria are immobilized and removed in the composition of detritus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9db283e7c5f968ceb2439827af310532 https://doi.org/10.1134/s1063784219010183 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.