Hygroscopic Growth and Deposition of Inhaled Secondary Cigarette Smoke in Human Nasal Pathways

Autor:	Ray Burton, Cynthia J. Musante, Dongming Hwang, Jeffry D. Schroeter, Ted B. Martonen, Ray Guilmette
Rok vydání:	2001
Předmět:	Inhalation Chemistry Particulates Pollution medicine.anatomical_structure Deposition (aerosol physics) Environmental chemistry medicine Environmental Chemistry Particle General Materials Science Particle size Sidestream smoke Respiratory system Respiratory tract
Zdroj:	Aerosol Science and Technology. 34:137-143
ISSN:	1521-7388 0278-6826
DOI:	10.1080/02786820117094
Popis:	To ascertain the threat to human health posed by the inhalation of the particulate phase for secondary cigarette smoke (SCS), it is necessary to determine the doses delivered to airway cells. The risk assessment of SCS particles is complicated by their hygroscopic properties. Inhaled particles that are hygroscopic may absorb the water vapor that is present in a warm, humid environment such as that found in the human respiratory system. As a direct result, the physicochemical characteristics of a particle such as size, shape, density, and composition may experience signie cant changes. Herein, the effects of hygroscopicity and deposition of SCS particles are examined in the nasopharyngeal region of the respiratory tract through which particles travel before entering the lung. To accomplish this goal, a computer model is dee ned to describe the anatomical features of the airways within the human head and throat. Then the effects of water vapor uptake and deposition on inhaled particle size distributions are formulated. The results of the simulations indicate that hygroscopicity is a critical factor affecting the dynamics of inhaled SCS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9dad27dcea1258f64ec35e42925c176c https://doi.org/10.1080/02786820117094 Zobrazit plný text záznamu