An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin
Autor: | Gary Tarpley, Alexander M. Sherwood, Poncho Meisenheimer, Robert B. Kargbo |
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Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Synthesis. 52:688-694 |
ISSN: | 1437-210X 0039-7881 |
Popis: | Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC, or aqueous workup. The synthesis furnishes psilocybin in five steps in 23% overall yield from an inexpensive acetoxyindole starting material. With specific focus on process control and impurity fate and removal, the improved procedure is amenable to providing high-quality psilocybin. |
Databáze: | OpenAIRE |
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