An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin

Autor:	Gary Tarpley, Alexander M. Sherwood, Poncho Meisenheimer, Robert B. Kargbo
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Psilocin Organic Chemistry medicine 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences medicine.drug Psilocybin
Zdroj:	Synthesis. 52:688-694
ISSN:	1437-210X 0039-7881
Popis:	Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC, or aqueous workup. The synthesis furnishes psilocybin in five steps in 23% overall yield from an inexpensive acetoxyindole starting material. With specific focus on process control and impurity fate and removal, the improved procedure is amenable to providing high-quality psilocybin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d9fe81843c076a964a61830aab7d5f2 https://doi.org/10.1055/s-0039-1691565 Zobrazit plný text záznamu