The Synthesis and Antimicrobial Screening of Some Novel AZA-Imidoxy Compounds as Potential Chemotherapeutic Agents

Autor:	Devendra Prakash Nagda, G. L. Talesara, Shilpi Jain
Rok vydání:	2006
Předmět:	Inorganic Chemistry Primary (chemistry) Chemistry Organic Chemistry Proton NMR Organic chemistry Antimicrobial Antimicrobial screening Biochemistry Combinatorial chemistry Amine derivatives
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 181:1665-1673
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500500366970
Popis:	Some novel azaimidoxy compounds viz. 2-{[(4-chlorophenyl)diazenyl]oxy}-1H-isoindole-1,3-(2H)-dione (Va), and 1-{[1-naphthyldiazenyl]oxy}pyrrolidine-2,5-dione (IVc), etc. have been synthesized by a simple diazotization reaction followed by a coupling with 2-hydroxy-1H-isoindole-1,3(2H)-dione (III)/1-hydroxypyrrolidine-2,5-dione (II) of corresponding aromatic primary amine derivatives at a suitable pH. A similar reaction with a [1,3]thiazolo[4,5-b]pyridin-2-amine (VIII) lead us to some interesting results variable with a pH. The structure of all synthesized compounds has been established by IR, 1H NMR, and mass studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.
Databáze:	OpenAIRE
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