Benchmarking different brands of silicone oils
| Autor: | Joachim Dresp |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vitreoretinal surgeon
02 engineering and technology Benchmarking Vitreoretinal surgery 021001 nanoscience & nanotechnology Pulp and paper industry Sensory Systems Silicone oil 03 medical and health sciences Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound 0302 clinical medicine chemistry 030221 ophthalmology & optometry Environmental science 0210 nano-technology Quality characteristics |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 259:13-20 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-020-04809-2 |
| Popis: | To compare the analytical quality characteristics of currently available CE-marked silicone oils used as ocular endotamponades in vitreoretinal surgery. Thirty-four samples of 12 brands were analysed. To assess the quality characteristics of silicone oils, we measured the oligosiloxane content and polydispersity, widely accepted as purity parameters. UV-active substances (> 220 nm) were analysed to draw conclusions about the integrity of primary packaging components. We identified significant differences in the impurity profiles of the products tested, which revealed oligosiloxane contents ranging from 220 nm) ranging from 0.2 to 3.8 AU. The quality characteristics of the analysed silicone oils vary significantly not only among different brands but also among batches of the same manufacturer. Manufacturers should communicate the purity and quality characteristics of their products in an understandable and clear manner. This involves providing a complete certificate of analysis with special focus on quality characteristics, to enable the vitreoretinal surgeon to differentiate between the effects of the silicone oil itself and those of impurities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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