Contribution of the Pro12Ala polymorphism of peroxisome proliferator-activated receptor Ɣ2 gene in relation to obesity
| Autor: | Wan Rohani Wan Taib, Rohayu Izanwati Mohd Rawi, Mohd Khairi Zahri, Atif Amin Baig, Apidi Emilia, Aliya Irshad Sani |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics chemistry.chemical_classification medicine.medical_specialty medicine.diagnostic_test Peroxisome proliferator-activated receptor 030209 endocrinology & metabolism Lipid metabolism Biology medicine.disease Obesity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Polymorphism (computer science) Internal medicine Genotype medicine Allele Lipid profile Genotyping Genetics (clinical) |
| Zdroj: | Meta Gene. 10:39-44 |
| ISSN: | 2214-5400 |
| DOI: | 10.1016/j.mgene.2016.09.008 |
| Popis: | Background and aims Peroxisome proliferator-activated receptor Ɣ2 (PPARƔ2) gene Pro12Ala polymorphism has been extensively studied in relation to obesity and its associated metabolic complications but the results were inconclusive. This study aimed to identify the genotypic and allelic frequencies of PPARƔ2 gene and its association with anthropometric measurements, lipid profiles and the susceptibility for obesity in Malay subjects. Methods and results This cross-sectional, comparative study involved 217 subjects (94 obese and 123 non-obese as controls). Anthropometric and lipid profiles were measured. Genotyping was performed by allele-specific PCR. Comparisons were made between the genotypes and the association of PPARƔ2 Pro12Ala polymorphism with obesity was evaluated. The Pro12Pro, Pro12Ala and Ala12Ala genotypic frequencies were significantly different between groups (88.3%/11.7%/0.0% vs. 97.6%/2.4%/0.0% respectively, P = 0.006).The Ala12 allele was more frequent in obese than the non-obese (5.9% vs. 1.1%, P = 0.007). Ala12 carriers were associated with higher BMI ( P = 0.016), BF% ( P = 0.019) and a trend towards higher BAI ( P = 0.055) than the non-carriers. Besides age, high level of triglycerides and LDL-cholesterol, Ala12 allele (Adjusted OR = 5.46, 95% CI = 1.27–23.40; P = 0.022) were regarded as independent risk factors for obesity. Conclusions This study indicates that the PPARƔ2 gene Pro12Ala polymorphism predisposes to obesity in Malay subjects and Ala12 allele could predict alterations in adipocyte and lipid metabolism among them. Age, triglycerides, LDL-cholesterol and Ala12 allele conferred to increased risk for obesity in this ethnicity. |
| Databáze: | OpenAIRE |
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