Optical resolution by crystalline inclusion formation using new lactic acid derived hosts

Autor:	Claus Wimmer, Edwin Weber
Rok vydání:	1993
Předmět:	Pharmacology Resolution (mass spectrometry) Chemistry Organic Chemistry Sorption Crystalline inclusion Optically active Catalysis Analytical Chemistry Lactic acid chemistry.chemical_compound Drug Discovery Organic chemistry Enantiomer Spectroscopy
Zdroj:	Chirality. 5:315-319
ISSN:	1520-636X 0899-0042
DOI:	10.1002/chir.530050507
Popis:	New optically active host compounds for chiroselective crystalline inclusion formation derived from natural lactic acid are synthesized. They enable useful enantiomer separations of different chiral compounds via cocrystallization and sorption on preparative scale including various ketones, lactones, alcohols, sulfoxides, and methyloxiranes. In the cases of 3-methylcyclohexanone, 4-methyl-δ-valerolactone, and 2-phenylpropanol, ees > 99% were obtained from one cocrystallization step using these hosts. © 1993 Wiley-Liss, Inc.
Databáze:	OpenAIRE
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