Ethylene oxide – Addendum: Derivation of BAR
| Autor: | Eckert, Elisabeth, Bader, Michael, Drexler, Hans, Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Blut
biological reference value toxicity Ethylenoxid occupational exposure Ethanepoxid Toxizität ethylene oxide Dimethylenoxid Gefahrstoff BAR Urin Hintergrundbelastung hazardous substance Biologischer Arbeitsstoff-Referenzwert biomonitoring background exposure 1 2-Epoxyethan Oxiran berufliche Exposition Ethanoxid |
| DOI: | 10.34865/bb7521e7_1ad |
| Popis: | The Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area of the Deutsche Forschungsgemeinschaft has evaluated biological reference values (BAR) for two metabolites of ethylene oxide [75-21-8]. Considering the available studies on the mercapturic acid of ethylene oxide in urine, S-(2-hydroxyethyl) mercapturic acid (HEMA), a BAR of 5 µg HEMA/g creatinine for background exposure to ethylene oxide was established. Sampling time after short-term exposures is at the end of exposure or at the end of the working shift. For long-term-exposures, a BAR of 60 pmol/g globin was established for the haemoglobin adduct of ethylene oxide, N-(2-hydroxyethyl) valine (HEV). Sampling time is after at least 3 months of exposure. |
| Databáze: | OpenAIRE |
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