Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C–H bond functionalization

Autor:	Kevin S. Eccles, Simon E. Lawrence, Adrian C. Whitwood, Marie Therese Nolan, Man Sing Cheung, Joshua T. W. Bray, Gerard P. McGlacken, Zhenyang Lin, Ian J. S. Fairlamb
Rok vydání:	2014
Předmět:	C h bond Chemistry Organic Chemistry Regioselectivity chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound Intramolecular force Reagent Drug Discovery Surface modification Organic chemistry Phosphine Palladium
Zdroj:	Tetrahedron. 70:7120-7127
ISSN:	0040-4020
Popis:	The intramolecular arylation of 2-pyrones, 2-pyridones, coumarins and quinolones is reported using PdII precatalyst sources without added phosphine ligands. The excellent yields and convenient reagents enables the formation of various analogues containing these moieties, and access to potential biologically active candidates. Stoichiometric studies were carried out to provide an insight into the oxidation addition step. A switch in regioselectivity, together with a hydrodebromination process, was observed in the case of a 3-bromo-2-pyrone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d80dd13a8fb5827bddc4c33c249cc1a https://doi.org/10.1016/j.tet.2014.04.029 Zobrazit plný text záznamu Full Text from ScienceDirect